Aortic Valve Replacement: Meta-Analysis Finds No Mortality Difference Between TAVI and SAVR

The mortality comparisons had wide confidence intervals, however, signaling inconclusive results.

Transcatheter aortic valve implantation (TAVI) is a better option than medical therapy for people with severe aortic stenosis who cannot undergo surgical aortic valve replacement (SAVR). However, there are some conflicting results regarding whether TAVI is a better option than SAVR for those who could undergo either.

Investigators in Italy identified 5 randomized trials and 31 observational studies in a systematic review and meta-analysis that focused on mortality after TAVI and SAVR. There were no statistical group differences by risk at the time of the procedure. The two strategies showed no statistical difference in early all-cause mortality (odds ratio, 1.01; 95% confidence interval, 0.81–1.26), midterm all-cause mortality (OR, 0.96; 95%…

Reviewing Author

Harlan M. Krumholz, MD, SM

Disclosures

Consultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime

EquityHugo Health; Refactor Health; Element Science

Grant/Research SupportPfizer; Agency for Healthcare Research and Quality; Janssen Research and Development, National Institute of Biomedical Imaging and Engineering; National Heart, Lung, and Blood Institute; Centers for Disease Control and Prevention; National Cancer Institute; American Heart Association

Harlan M. Krumholz, MD, SM

Disclosures

Consultant/Advisory BoardUnited Healthcare; Element Science; Eyedentifeye, F-Prime

EquityHugo Health; Refactor Health; Element Science

Aortic Valve Replacement: Meta-Analysis Finds No Mortality Difference Between TAVI and SAVR

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Reviewing Author