Support for Polio Vaccine Schedule with Bivalent Oral Poliovirus plus Inactivated Poliovirus Vaccine

Bivalent oral poliovirus vaccine was as effective as trivalent OPV in eliciting immune response against types 1 and 3 polioviruses.

The transition to a world without transmission of wild polioviruses involves eliminating use of live oral poliovirus vaccines in favor of inactivated poliovirus vaccine (IPV). Oral poliovirus vaccine (OPV) for serotype 2, the virus responsible for about 97% of all circulating vaccine-derived polioviruses, was withdrawn as of April 2016; bivalent OPV (bOPV) is replacing trivalent OPV (tOPV) during the transition phase.

In a multicenter study in Latin America, investigators aimed to inform decisions about future polio immunization schedules. They assessed whether one or two doses of IPV along with three doses of bOPV (serotypes 1 and 3) were superior to three doses of bOPV only, by checking effects on intestinal and humoral immunity against ty…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Support for Polio Vaccine Schedule with Bivalent Oral Poliovirus plus Inactivated Poliovirus Vaccine

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Reviewing Author