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Standard proton-pump inhibitor (PPI)–based triple therapy for Helicobacter pylori eradication has demonstrated decreasing efficacy as antibiotic resistance increases. Investigators retrospectively compared the eradication of H. pylori in 175 propensity-score–matched pairs of patients treated in a single Japanese hospital during a 34-month period. All patients received amoxicillin 750 mg and clarithromycin 200 mg twice daily for 7 days. In addition, one group received a PPI (lansoprazole 20 mg or rabeprazole 30 mg), and another received a potassium-competitive acid blocker (P-CAB; vonoprazan 20 mg), each twice daily for 7 days. H. pylori eradication was evaluated by a breath test or stool antigen test.
The eradication rate was significantly h…