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Accurately predicting cardiovascular risk is crucial when targeting preventive therapies. Despite the many available risk scores, investigators are always looking to improve risk prediction. With that goal, researchers in an industry-funded study measured 1130 proteins in 938 plasma samples from patients with stable coronary heart disease (CHD) in the prospective Heart and Soul study.
The primary outcome (myocardial infarction, stroke/transient ischemic attack, hospitalization for heart failure, or all-cause death) was associated with 200 proteins (145 positively; 55 negatively). The final model, reflecting the probability of a cardiovascular event occurring within 4 years, used 9 proteins (angiopoietin-2, matrix metalloproteinase-12, chemok…