Poor CD4 Recovery After ART Linked to Increased Mortality

A review of the literature concludes that discordant immune recovery on antiretroviral therapy is associated with a marked increase in mortality in most studies.

A discordant immune response (DIR) is loosely defined as a failure to observe a satisfactory increase in CD4-cell counts on antiretroviral therapy (ART) despite good viral suppression. The authors systematically evaluated studies assessing the effect of DIR on mortality, AIDS, and serious non-AIDS events. They included cohort studies and cohorts contained in arms of randomized controlled trials, for adults aged ≥16 years. They used the Cochrane tool to measure bias. For this analysis, DIR was classified as suboptimal CD4-cell count, as defined by each study, despite viral suppression after at least 6 months of ART.

Of 2782 study titles, 20 studies met the inclusion criteria. The included studies used a total of 14 definitions of DIR. The ove…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Poor CD4 Recovery After ART Linked to Increased Mortality

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Reviewing Author