High Risk for Metachronous Advanced Neoplasm with Sessile Serrated Polyp plus High-Risk Adenoma

In several studies, patients with a combination of serrated lesions plus conventional adenomas are shown to be at increased risk for subsequent development of metachronous advanced lesions and cancer.

In the current prospective study, researchers compared risk for advanced neoplasm development across four patient groups categorized by baseline colonoscopy findings (normal, low-risk adenomas, high-risk adenomas, and sessile serrated polyps [SSPs]). Advanced neoplasm was defined as adenoma with size >1 cm or villous component >75% and/or high-grade dysplasia.

Risk for developing advanced neoplasm was 0.2 per 1000 person-months in those with normal baseline colonoscopies, 1.5 in those with low-risk adenomas, and 1.4 in patients who had SSPs with…