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Gastric intestinal metaplasia (GIM) is a step in the progression to gastric cancer (GC), but risk for GC varies among different populations. To determine GC risk in U.S. patients with GIM, investigators reviewed the records of a community-based healthcare system in Southern California and identified 923 patients with GIM.
Overall, 25 GIM patients also developed GC (adjusted incidence rate, 1.7; 95% confidence interval, 0.7–3.4). In 17 of these patients, both diagnoses were made at the same time; in the other 8, median time between diagnoses of GIM and GC was 4.6 years. Family history was identified as a risk factor for GC (hazard ratio, 3.8; 95% CI, 1.5–9.7). A case-cohort analysis of the 8 patients with GIM who then developed GC and 40 matc…