Abnormal Uterine Bleeding as a Red Flag for Cancer: Rare but Real

Hematologic malignancies can cause AUB in young women.

Nonstructural causes of abnormal uterine bleeding (AUB) include cancer-related coagulopathies. To estimate the proportion of women with hematologic malignancies who initially present with AUB, investigators conducted a retrospective analysis of 10,682 women with hematologic cancer who were treated at MD Anderson Cancer Center over a 14-year interval.

One postmenopausal woman and 37 premenopausal women (overall median age, 34) had new-onset AUB as their chief presenting symptom; thus, an estimated 3.6 per 1000 women with hematologic cancer presented initially with AUB. All 37 premenopausal women described their AUB as “significantly heavier than in previous, normal cycles.” The most common accompanying symptoms were fatigue (58%), dyspnea (42…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Abnormal Uterine Bleeding as a Red Flag for Cancer: Rare but Real

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Reviewing Author