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Complications from long-term deep sedation and the lack of adequate pain control for mechanically ventilated intensive care unit (ICU) patients has resulted in the development of analgosedation protocols emphasizing pain control over sedation. Most approaches utilize remifentanil. These investigators conducted a retrospective cohort study of adult medical ICU patients intubated before and after the implementation of a fentanyl-based analgosedation protocol.
Patients who were intubated for more than 24 hours and qualified for lighter levels of sedation were included. Patients extubated during the immediate postoperative period, transferred on a ventilator, or moribund on arrival were excluded. The preimplementation group was managed with prop…