Can a MRSA-Treatment Bundle Reduce Hospital-Onset Gram-Negative Rod Bacteremia?

Hospital-onset GNR bacteremia declined significantly; community-acquired GNR bacteremia did not.

In 2007, the Veterans Health Administration (VHA) introduced the methicillin-resistant Staphylococcus aureus (MRSA) Prevention Initiative, which mandated implementation of a treatment bundle that included both pathogen-specific, vertical infection-control measures and nonpathogen-specific, horizontal infection-control measures.

Theorizing that the bundle might have effects beyond MRSA and, specifically, that the horizontal components would reduce the frequency of hospital-onset gram-negative rod (HO-GNR) bacteremia, investigators conducted a retrospective, observational cohort study using time-series analysis of 47,480 instances of bacteremia due to Escherichia coli, Klebsiella, and Pseudomonas aeruginosa at 130 VHA hospitals from 2003 throu…

Reviewing Author

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Can a MRSA-Treatment Bundle Reduce Hospital-Onset Gram-Negative Rod Bacteremia?

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Reviewing Author