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To summarize clinical features of the recent uptick in acute flaccid myelitis (AFM) cases in the U.S., researchers reviewed all English language reports between January 1, 2012 and July 1, 2016 of acute flaccid paralysis with radiographic or electrophysiologic evidence of spinal cord gray matter/anterior horn cell disease. Cases came from California (n=59), Colorado (n=12), and Utah (n=11) and from Centers for Disease Control and Prevention surveillance data (n=120, 43 of whom were included in the other cohorts).
Most cases occurred in previously healthy children. A febrile respiratory or gastrointestinal prodrome was common before the rapid onset of neurologic symptoms. Limb weakness was frequently asymmetric and sensory involvement variabl…