Can We Predict Response to Antidepressants?

Early life stress combined with amygdala responsivity on imaging was sensitive and specific in predicting therapeutic response.

Early life stress (ELS) and the response of the amygdala to stressful stimuli may be mechanisms for the development of depression. To evaluate whether the interaction of baseline amygdala responsivity and history of ELS has a relationship to antidepressant response, researchers analyzed data from the industry-funded International Study to Predict Optimized Treatment in Depression (iSPOT-D). ELS was determined on a rating scale, and amygdala responsivity to happy or fearful faces compared with neutral faces was measured on functional magnetic resonance imaging (fMRI).

The analyzed sample consisted of 70 individuals with depression, divided by ELS history and functional remission status. Patients had been randomized to escitalopram (mean dose,…

Reviewing Author

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Can We Predict Response to Antidepressants?

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Reviewing Author