Long-Term Use of Proton Pump Inhibitors Did Not Adversely Affect Measures of Bone Strength

In a Canadian study, no differences in BMD or indexes of bone strength or turnover were seen in PPI users compared with nonusers.

Several population studies have suggested a weak association between proton pump inhibitor (PPI) use and hip fractures (e.g., NEJM JW Gastroenterol Jul 2010 and Arch Intern Med 2010; 170:765); however, strong evidence of causality and a clear mechanism for this effect are lacking. Investigators in Manitoba assessed bone strength and structure in 52 patients with >5 years of PPI use compared with 52 matched nonusers (mean overall age, 65). Areal bone mineral density (BMD) and associated T-scores were determined with DXA scanning; bone structure was evaluated with three-dimensional quantitative computed tomography (3D-QCT) for volumetric BMD (vBMD) and cortical bone mineral mass. Metabolic markers of bone turnover and osteoblast activity were…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Long-Term Use of Proton Pump Inhibitors Did Not Adversely Affect Measures of Bone Strength

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Reviewing Author