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Colorectal polyps with endoscopic features suggesting deep submucosal invasion (e.g., ulceration, or NICE type 3 vascular changes) should be sent directly for surgical resection. However, superficial submucosal invasion can be difficult to predict endoscopically, and these patients commonly undergo attempts at endoscopic resection. Some studies suggest that endoscopic resection of an early colorectal cancer could increase the growth rate of the cancer and the risk for metastasis. The current retrospective cohort study attempts to address whether this phenomenon really occurs.
From among 13 hospitals in the Netherlands, researchers identified 602 patients treated between 2000 and 2014 who had T1 cancers and unfavorable histologic features (po…