Loading...
Evidence suggests that, in people with previous colorectal neoplasia, aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower risk for metachronous neoplasia (i.e., occurring after resection of initial neoplasia). In this network meta-analysis of 14 randomized trials that involved 12,000 adults with previous colorectal neoplasia (either polyps or cancer with curative resection), researchers determined the comparative effectiveness and safety of candidate chemopreventive agents in preventing advanced colorectal neoplasia (villous component, high-grade dysplasia, or cancer) within 5 years of the colonoscopy that identified the initial polyps or cancer. Candidate agents were compared head-to-head or with placebo.
Nonaspirin NSAIDs (i.e.…