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In the past, multifocal low-grade dysplasia (LGD) verified by an expert pathologist was considered an indication for colectomy in ulcerative colitis, whereas unifocal LGD could be followed by intense surveillance or colectomy. An emerging concept is that nearly all dysplasia in ulcerative colitis is endoscopically visible, particularly with chromoendoscopy, and that endoscopically resected dysplasia can be followed in surveillance.
Researchers conducted a meta-analysis to estimate the risk for progression of LGD to colorectal cancer (CRC) in patients with ulcerative colitis undergoing periodic surveillance after diagnosis of LGD. Fourteen surveillance cohort studies were included comprising 671 patients whose LGD was identified primarily in …