Shifting Etiologies of Advanced Liver Disease in the U.S.

As HCV infection decreases, obesity- and alcohol-related liver disorders account for increasing proportions of advanced liver disease.

With the advent of highly effective therapies for hepatitis C virus (HCV) infection and the ongoing obesity epidemic, the proportional burdens of HCV infection, nonalcoholic fatty liver disease (NAFLD), and alcohol-related liver disease (ALD) on liver disease and liver transplantation waiting times are expected to change.

To evaluate those changes, investigators analyzed data from a nationally representative U.S. health examination survey (data periods, 2010 and 2013–2014); a research database comprising data on commercially insured patients with cirrhosis, including decompensated disease (2006–2014); and national transplantation data (2013–2015). Results were as follows:

The prevalence of HCV infection (HCV RNA positivity) in the U.S. declin…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Shifting Etiologies of Advanced Liver Disease in the U.S.

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Reviewing Author