Does Methotrexate Enhance Benefit of Intraarticular Steroids in Oligoarticular JIA?

After 12 months of therapy, remission in injected joints was similar with or without methotrexate.

Oligoarticular (affecting ≤4 joints) juvenile inflammatory arthritis (JIA) is a common type of pediatric chronic arthritis in white children. It leads to progressive joint involvement in 25% to 50% of patients. Intraarticular corticosteroids are typically used to treat this condition, though evidence-based therapeutic guidance is scant.

In the current prospective, open-label trial, investigators in Italy evaluated whether adding methotrexate to intraarticular corticosteroid therapy increased efficacy in achieving clinical arthritis remission. They randomized 207 children with oligoarticular JIA to receive intraarticular corticosteroids alone or in combination with oral methotrexate (15 mg/m²; maximum dose, 20 mg) plus folinic acid weekly for…

Reviewing Author

F. Bruder Stapleton, MD

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Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Does Methotrexate Enhance Benefit of Intraarticular Steroids in Oligoarticular JIA?

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Reviewing Author