Can an Aspirin a Day Lower Risk for Pregnancy Loss?

Low-dose aspirin increased live-birth rates in some women with prior pregnancy loss and high levels of high-specificity C-reactive protein.

Chronic inflammation has been implicated as a cause of pregnancy loss. High-specificity C-reactive protein (hsCRP), a marker of chronic inflammation, is commonly moderately elevated in individuals at excess risk for cardiovascular mortality. Daily low-dose aspirin (LDA; 81 mg) can safely lower this risk; moreover, LDA is recommended to prevent preeclampsia (Ann Intern Med 2014; 161:819). Investigators conducted a randomized trial in which LDA or placebo was administered to 1228 women (age range, 18–40) who were attempting to conceive after 1 or 2 prior pregnancy losses. Participants received study pills for six menstrual cycles or until gestational week 36. To determine whether any benefit of LDA on pregnancy and live-birth rates was affect…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Can an Aspirin a Day Lower Risk for Pregnancy Loss?

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Reviewing Author