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In a recently published, industry-funded, randomized trial that involved about 300 men (mean age, 68; morning total testosterone range, 100–400 ng/dL), subclinical atherosclerosis was the primary endpoint. During 3 years of treatment with testosterone gel or placebo, changes in carotid intima-media thickness and coronary artery calcium were similar in the two groups (NEJM JW Gen Med Sep 15 2015 and JAMA 2015; 314:570). Now, the researchers report the following additional study outcomes on quantitative measures of muscle performance and physical function:
Chest-press strength, but not leg-press strength, improved with testosterone compared with placebo.
Chest-press and leg-press power (a measure of the rate at which muscle generates force) bot…