Carbapenem-Resistant Enterobacteriaceae in the Greater New York/New Jersey Region

Most of these multiresistant pathogens were carbapenemase-producing K. pneumoniae, and 30-day mortality approached 50%, regardless of active antibiotic treatment.

Enterobacteriaceae resistant to carbapenems (CRE), a major worldwide problem, usually carry plasmids that encode for resistance to numerous antibiotics besides carbapenems, making them virtually untreatable.

To study prevalence and epidemiology of CRE, researchers in eight medical centers in the greater New York/New Jersey area — one epicenter for CRE —conducted an observational cohort study involving 1133 bloodstream infections with Klebsiella pneumoniae, 2550 with Escherichia coli, and 279 with Enterobacter. Among these, 121 were caused by CRE, the vast majority bla_KPC-carbapenemase producing K. pneumoniae. Carbapenem resistance was seen in 9.7%, 0.1%, and 2.2% of K. pneumoniae, E. coli, and Enterobacter isolates, respectively, and varied …

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Carbapenem-Resistant Enterobacteriaceae in the Greater New York/New Jersey Region

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Reviewing Author