Loading...
Therapy-induced cancers are the most common cause of death other than relapse in children and adolescents who survive at least 5 years from a cancer diagnosis.
To investigate temporal trends in secondary cancer diagnoses, investigators conducted a long-term analysis of the Childhood Cancer Survivor Study (J Clin Oncol 2009; 27:2308), a retrospective cohort study of survivors of childhood cancer at 27 pediatric cancer treatment centers in the U.S. and Canada. The investigators expanded the study to include follow-up of more than 23,000 patients who received a cancer diagnosis before the age of 21 years (mean age at diagnosis, 7.7 years) from 1970 to 1999, with follow-up through 2015.
During a mean follow-up of 20.5 years, 1026 secondary malign…