A meta-analysis showed that antipyretic therapy did not reduce 28-day mortality.
Fever is certainly a sign of infection. But does treatment of fever improve outcomes in patients with sepsis?
To find out, investigators conducted a meta-analysis of eight randomized trials (1507 patients) and six observational studies (2058 patients) that compared outcomes in adult patients with sepsis according to whether or not they were treated with antipyretics. Two additional observational studies examined early mortality in 15,374 patients.
The analysis showed that the primary outcome of 28-day mortality was not significantly different between patients who received antipyretics versus those who did not (relative risk, 0.93; 95% confidence interval, 0.79–1.09). Moreover, no significant between-group differences were observed in the seco…
Reviewing Author
DisclosuresRoyaltiesUpToDate
Grant/Research SupportEunice Kennedy Shriver National Institute of Child Health and Human Development; MINDSOURCE
Editorial BoardsThe Quarterly Update: Reviews of Current Child Abuse Medical Research; Child Abuse & Neglect: The International Journal
Leadership Positions in Professional SocietiesThe Helfer Society (Executive Committee Member)
DisclosuresRoyaltiesUpToDate
Grant/Research SupportEunice Kennedy Shriver National Institute of Child Health and Human Development; MINDSOURCE
Editorial BoardsThe Quarterly Update: Reviews of Current Child Abuse Medical Research; Child Abuse & Neglect: The International Journal
Leadership Positions in Professional SocietiesThe Helfer Society (Executive Committee Member)