Evidence that Fetal Exposure to Quadrivalent HPV Vaccine During Pregnancy Is Safe

Maternal human papillomavirus vaccination did not confer excess risk for several adverse pregnancy outcomes.

Evaluating the safety of vaccination during pregnancy is complicated by the general avoidance of routine immunizations other than those that are indicated (e.g., influenza vaccine); hence, reliable data are sparse regarding outcomes in women who inadvertently received the human papillomavirus (HPV) vaccine before becoming aware they were pregnant. Investigators queried nationwide prospective medical records of pregnant Danish women from October 2006 to November 2013 to determine whether outcomes differed among women who received the quadrivalent HPV vaccine during pregnancy versus those who did not. About 500,000 singleton pregnancies were identified, including some 1700 exposed to the vaccine.

Analyses adjusted for potential confounders sho…

Reviewing Author

Anna Wald, MD, MPH

Disclosures

Consultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)

RoyaltiesUpToDate

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris

Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases

Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)