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Postmarketing surveillance has raised concerns that 5α-reductase inhibitors might increase risk for depression and suicide; the biologic plausibility of this association is supported by evidence that these drugs affect neuropeptides, testosterone, and other neurotransmitters. In this retrospective Canadian study, researchers identified about 93,000 older men (mean age, 75) who started new prescriptions for finasteride or dutasteride between 2003 and 2013; these men were matched by age, history of depression or suicidal thoughts, and other demographic and clinical variables with an equal number of men without such prescriptions. Data also were collected on suicide, new-onset depression, and self-harm (e.g., hospitalization or emergency depar…