A Negative High-Sensitivity Troponin and Nonischemic ECG Can Rule Out AMI

However, samples for the troponin assay should be drawn at least 3 hours after symptom onset, and a positive troponin does not rule in acute myocardial infarction.

Several studies have demonstrated the potential utility of high-sensitivity cardiac troponin T (hs-cTnT) assays combined with electrocardiograms (ECGs) in the rapid rule-out of acute myocardial infarction (AMI) in adults presenting to the emergency department with chest pain (NEJM JW Emerg Med May 2010 and Circulation 2010; 121:1227; NEJM JW Emerg Med Jul 2016 and JAMA Cardiol 2016; 1:397; NEJM JW Emerg Med Sep 2016 and Ann Emerg Med 2016; 68:649). Researchers have now conducted a meta-analysis to determine the sensitivity of a single negative hs-cTnT plus a nonischemic ECG for ruling out AMI in these patients.

A total of 11 studies with 9241 patients (64% men, mean age 61 years) met inclusion criteria. Of included patients, 2825 (30.6%) wer…

Reviewing Author

Ali S. Raja, MD, MBA, MPH

Disclosures

Leadership Positions in Professional SocietiesSociety for Academic Emergency Medicine (Board Member); American College of Healthcare Executives – Massachusetts (Board Member)

Ali S. Raja, MD, MBA, MPH

Disclosures

Leadership Positions in Professional SocietiesSociety for Academic Emergency Medicine (Board Member); American College of Healthcare Executives – Massachusetts (Board Member)

A Negative High-Sensitivity Troponin and Nonischemic ECG Can Rule Out AMI

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Reviewing Author