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Asymptomatic microscopic hematuria (AMH; defined by red blood cells on urine microscopy, not dipstick testing) raises concerns about occult genitourinary cancer. In this decision analysis, investigators used standard research sources and evidence-based assumptions to assess the cost-effectiveness of detecting genitourinary cancer with each of four strategies:
Combination computed tomography (CT) urography and cystoscopy
Combination renal ultrasound and cystoscopy
Cystoscopy alone
CT urography alone
Neither ultrasound alone nor voided-urine cytology were evaluated, due to their relatively poor sensitivity.
Combination renal ultrasound and cystoscopy was the most cost-effective, with an incremental cost per cancer detected of about US$53,000. Subst…