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The spectrum of lymphoproliferative malignancies becomes increasingly complex as new, biologically and clinically relevant subtypes are identified. To assess the clinical impact of formal hematopathology review on all lymphoma cases prior to treatment initiation, French investigators conducted a nationwide government-sponsored prospective study of diagnostic cutaneous and noncutaneous samples from patients with newly diagnosed or suspected lymphoma from 2010 through 2013.
Cases were classified according to the WHO 2008 Classification of Tumours of the Haematopoietic and Lymphoid Tissues. The final expert diagnosis was compared with that submitted by the referring pathologist, with differences classified as major (i.e., with potential impact …