Genetic Susceptibility Is Key in Early-Onset Pancreatitis in Children

Acute recurrent or chronic pancreatitis is more likely to be associated with a genetic mutation when diagnosed before age 6 years versus after.

Mutations in cationic trypsinogen (PRSS1) and chymotrypsin C (CTRC) are known to be associated with childhood pancreatitis. To determine whether genetic mutations are associated with age of onset of acute pancreatitis that leads to acute recurrent pancreatitis (ARP) or chronic pancreatitis (CP), investigators reviewed clinical data from 342 children with ARP or CP. Patients were categorized by age at initial diagnosis of acute pancreatitis: <6 years (38%), considered early-onset pancreatitis (EOP); 6–11 years (32%); and ≥12 years (30%). Results were as follows:

CP rates did not differ between the three age-of-onset groups.
At least one genetic mutation associated with pancreatitis was found in 71% of children with EOP, significantly more freq…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Genetic Susceptibility Is Key in Early-Onset Pancreatitis in Children

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Reviewing Author