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Recent studies demonstrate that medical therapies such as corticosteroids improve only short-term survival in severe alcoholic hepatitis (SAH). Understanding the variables that impact long-term survival could lead to identification of important modifiable factors and more-effective management tools.
In a prospective study in France, researchers assessed the contributions of factors such as baseline disease severity, extent of response to therapy, and alcohol relapse on short-term (within 6 months) and long-term (after 6 months) survival in 398 patients with SAH receiving corticosteroid treatment. Median long-term follow-up was approximately 5 years. Analysis was performed using Cox regression.
Results were as follows:
Sixty percent of patients…