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About half of patients with diabetes mellitus develop sensorimotor polyneuropathy. Current treatment targets vascular changes, but there is good evidence that neuronal changes take place before or in conjunction with vascular abnormalities. Intensive blood glucose control in type 1 diabetes mellitus has been shown to decrease the incidence of diabetic sensorimotor polyneuropathy and slow the progression of nerve injury.
For this single-arm, open-label pilot trial, researchers recruited 40 participants (53% female) with type 1 diabetes mellitus and a Toronto Clinical Neuropathy score of ≥1. Participants took 10 mg daily of seal oil omega-3 polyunsaturated fatty acids (ω-3PUFA) for 12 months. The investigators hypothesized that omega-3 supplem…