Next-generation metagenomic sequencing showed that almost 11% had this novel virus; its contribution to human disease is unknown.
Next-generation metagenomic sequencing (NGMS) has revealed the presence of novel microbial pathogens in previously unexplained medical conditions. A few years ago, a new virus, called human hepegivirus-1 (HHpgV-1), was discovered by NGMS in blood donors and blood transfusion recipients (MBio 2015; 6:e01466). HHpgV-1 shares similarities with hepatitis C virus (HCV) and human pegivirus (formerly GB virus C or hepatitis G virus). Now, researchers report detecting HHpgV-1 in people who inject drugs.
Eighteen plasma samples from HIV/HCV coinfected patients were subjected to NGMS. A total of 600 million nucleic acid sequences were identified; among these were sequences that aligned with HIV and HCV (which the participants were already known to hav…
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DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)