Are Proton-Pump Inhibitors Associated with Chronic Kidney Disease?

Associated? Yes. Proven causal? No.

Many recent observational studies suggest associations between proton-pump inhibitor (PPI) use and a host of different disorders (NEJM JW Gastroenterol Jun 13 2017; [e-pub] and Gastroenterology 2017 May 18; [e-pub]).

To evaluate whether PPI use is associated with chronic kidney disease (CKD), researchers retrospectively analyzed serum creatinine measurements in approximately 100,000 new PPI users and 10,000 new users of histamine-2–receptor antagonists (H₂RAs) in a cohort of Swedish patients. Median follow-up was 2.7 years after initial drug exposure.

PPI users were more likely to have a doubling of serum creatinine (hazard ratio, 1.3) or a 30% decrease in estimated glomerular filtration rate (EGFR; HR, 1.3) compared with nonusers. The associ…

Reviewing Author

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

David J. Bjorkman, MD, MSPH (HSA), SM (Epid.)

Disclosures

Nothing to disclose

Are Proton-Pump Inhibitors Associated with Chronic Kidney Disease?

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Reviewing Author