Vitamin C, Thiamine, and Hydrocortisone for Sepsis Patients

A single-center study showed remarkable mortality reduction with this cocktail.

A myriad of interventions for sepsis have been studied; the vast majority have been disappointing. Despite such setbacks, the search persists for the right combination of agents to stop inflammatory dysregulation.

During 6 months, all patients admitted to the medical intensive care unit (MICU) in a Norfolk, VA, hospital with severe sepsis or septic shock and elevated procalcitonin levels (≥2 ng/mL), received intravenous high-dose vitamin C (6 g daily), hydrocortisone (50 mg every 6 hours), and thiamine. In a before–after study design, 47 intervention patients were compared with 47 patients who had been admitted to the MICU in the 6 months prior to implementation. Patients in the two groups had remarkably similar baseline characteristics.

Mort…

Reviewing Author

Patricia Kritek, MD

Disclosures

Editorial BoardsATS Scholar

Patricia Kritek, MD

Disclosures

Editorial BoardsATS Scholar

Vitamin C, Thiamine, and Hydrocortisone for Sepsis Patients

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Reviewing Author