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Atherosclerosis is a disorder characterized by the accumulation of macrophages in atheromatous plaques. Macrophages that have differentiated from clones of hematopoietic stem cells with mutations in DNMT3A, Tet2, and ASXL1 produce increased amounts of inflammatory cytokines and might be atherogenic.
To test the hypothesis that clonal hematopoiesis of indeterminate potential (CHIP) is a risk factor for atherosclerosis, investigators analyzed data from prior case-control studies encompassing 4726 participants with coronary heart disease (CHD) and 3529 controls. Whole exome sequencing focused on 74 genes known to be recurrently mutated in myeloid cancers. In addition, gene-expression analysis was conducted on Tet2 knockout macrophages transplan…