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Portal hypertension–related complications drive most of the morbidity and mortality in hepatitis C virus (HCV)–infected patients with cirrhosis. It is unclear if portal hypertension improves after sustained virologic response (SVR) in HCV-infected patients with pretreatment clinically significant portal hypertension (CSPH).
In a multicenter prospective study, researchers in Spain assessed the effect of achieving SVR on liver, pulmonary, and systematic hemodynamics in patients with HCV-related cirrhosis and CSPH, defined as hepatic venous pressure gradient (HVPG) ≥10 mm Hg. HVPG was measured at baseline and 24 weeks after completing an interferon-free anti-HCV treatment regimen.
Among 226 patients, 75% had esophageal varices, 21% had Child-Pug…