A New Live Attenuated Pertussis Vaccine Protects Against Disease and Colonization

A single intranasal/intratracheal dose of BPZE1 protected baboons from disease and resulted in >99.9% reduction in nasopharyngeal colonization.

Pertussis is resurgent despite global vaccination rates of >85%. One possible reason is the persistent reservoir of asymptomatic carriers of Bordetella pertussis. The effect of vaccination on asymptomatic nasal colonization has been difficult to assess in animal models, but a recently developed baboon model indicates that neither a whole-cell or acellular vaccine was completely protective. In contrast, prior infection with B. pertussis results in sterilizing immunity.

Now, French and American researchers conducted an industry-sponsored study involving 10 healthy juvenile baboons to test a new live attenuated B. pertussis vaccine, BPZE1, that was found to be safe in preclinical trials. Vaccination and infection occurred intranasally and intra…

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

A New Live Attenuated Pertussis Vaccine Protects Against Disease and Colonization

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Reviewing Author