Effective Strategies to Prevent Posttransplant Lymphoproliferative Disease in High-Risk Adults

Monitoring of Epstein-Barr virus viral load, but not antiviral prophylaxis, was associated with fewer cases of posttransplant lymphoproliferative disease in high-risk, adult, solid-organ transplant recipients.

Because most adults are infected with Epstein-Barr virus (EBV; 90%–95%), studies of adults at high risk for donor-positive/recipient-negative (D+/R−) posttransplant lymphoproliferative disease (PTLD) are limited. Common strategies to prevent PTLD include antiviral prophylaxis and reducing immunosuppression in patients who develop EBV viremia, but these strategies have not been well studied in a high-risk adult population.

These authors conducted a retrospective, single-center study of 153 adult EBV D+/R− solid-organ transplant recipients. The use of viral load monitoring and antiviral prophylaxis was at the discretion of treating physicians. Of 55 patients undergoing routine monitoring for EBV viremia, 37 (67.2%) developed viremia. An additi…

Reviewing Author

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Daniel Kaul, MD

Disclosures

Grant/Research SupportNobelpharma; Pfizer

Leadership Positions in Professional SocietiesAmerican Society of Transplantation (Program Committee)

Effective Strategies to Prevent Posttransplant Lymphoproliferative Disease in High-Risk Adults

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Reviewing Author