ACOG Updates Guidelines for Management of Hereditary Breast and Ovarian Cancer Syndrome

Obstetrician-gynecologists play key roles, but should consider referral to a genetic specialist as necessary.

Sponsoring Organization: American College of Obstetricians and Gynecologists (ACOG)

Target Population: Women's healthcare providers

Background and Objective

BRCA1 and BRCA2 mutations account for 4% of breast cancer cases and up to 24% of epithelial ovarian cancer cases, making these mutations the most common cause of hereditary breast and ovarian cancer syndrome. Estimated risk for breast cancer by age 70 is 45% to 85% (BRCA1 or 2) and, for ovarian cancer, 39% to 46% (BRCA1) or 10% to 27% (BRCA2). Prevalence of BRCA mutations is relatively high in certain populations (e.g., 1 in 40 among Ashkenazi Jews of European ancestry). Now, ACOG has updated its guidance for assessing and managing hereditary breast and ovarian cancer.

Key Recommendations

Ge…

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health