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Patients with early gastric cancer (EGC) have a risk for developing metachronous neoplasia (MN; dysplasia or carcinoma) in the remaining stomach after endoscopic dissection. Investigators in Korea retrospectively evaluated whether persistent Helicobacter pylori infection and changes in pepsinogen (PG) levels are associated with risk for MN among nearly 600 patients who underwent endoscopic dissection for EGC. Endoscopies and H. pylori testing were performed at 3 months, 9 months and annually postprocedure.
During a mean follow-up of 4 years, 64 patients (11%) developed MN. Persistent H. pylori infection and a serum PGI:PGII ratio ≤3 at the time of endoscopic therapy were associated with threefold and twofold elevated risks for MN, respective…