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For patients with first-episode psychosis, depressive and psychotic symptoms and quality of life improve more with comprehensive treatment programs than with usual community care. In a 2-year study, researchers examined treatment efficacy with NAVIGATE, a comprehensive protocol that employs specific manual-based medication guidelines, computer-supported shared decision making about medication, psychoeducation, resilience-focused individual therapy, and supported employment.
Based on efficacy and adverse effects, NAVIGATE suggests stage-1 medications (aripiprazole, quetiapine, risperidone, and ziprasidone), stage-2 medications for inadequate responders (stage-1 medications plus chlorpromazine, haloperidol, and olanzapine), and clozapine for s…