A Model Quantitates Tobacco-Related Mortality in HIV-Positive Smokers

Antiretroviral therapy–adherent smokers are far more likely to die from lung cancer than from AIDS-related complications.

Effective antiretroviral therapy (ART) provides HIV-positive patients with almost complete protection against classic AIDS-related opportunistic infections and malignancies. It appears to work less well against other conditions for which HIV raises risk, such as cardiovascular disease and lung cancer.

Researchers used published data to construct a model for lung cancer–related mortality among HIV-positive smokers who were engaged in care. For ongoing heavy smokers, overall cumulative lung cancer–related mortality by age 80 was projected to be 27% to 30% — considerably higher than similarly calculated rates in the general population (20%–24%). Estimated cumulative mortality was 16% to 19% among HIV-positive light smokers and 2% to 13% among f…

Reviewing Author

Abigail Zuger, MD

Disclosures

Nothing to disclose

Abigail Zuger, MD

Disclosures

Nothing to disclose

A Model Quantitates Tobacco-Related Mortality in HIV-Positive Smokers

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Reviewing Author