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Various proton-pump inhibitors (PPIs) are used in different doses to achieve similar clinical results. To suggest ideal dosing regimens of different PPIs, investigators performed a meta-analysis of 56 randomized trials that compared PPI doses to changes in gastric pH.
The analysis included a total of 3713 patients in 146 study groups who took PPIs once daily (116 groups), twice daily (25 groups), or three times daily (5 groups). Median daily time with a gastric pH ≤4 (pH4 time) was compared among the groups after 5 days of oral PPI administration. Data were reviewed based on previously determined omeprazole equivalents (OEs; Eur J Clin Pharmacol 2009; 65:19), ranging from 4.5 mg of pantoprazole to 36 mg of rabeprazole being equivalent to 20 …