Biomarkers of Ovarian Reserve Are Not Always Effective for Predicting Conception

Low AMH and high FSH levels may be of little use for estimating reproductive potential in noninfertile women who delay pregnancy.

Serum levels of antimüllerian hormone (AMH) and early-follicular-phase follicle-stimulating hormone (FSH) are used routinely to help predict the response to controlled ovarian hyperstimulation prior to in vitro fertilization. Increasingly, these biomarkers are being utilized to estimate fertility potential in women who delay pregnancy until later in reproductive life; but is this strategy effective? In a time-to-pregnancy cohort study involving 750 women (mean age, 33) who had been attempting to conceive for ≤3 months, investigators evaluated the associations between biomarkers of ovarian reserve and reproductive potential as defined by a positive pregnancy test.

After adjusting for variables such as age, race, body-mass index, smoking, and …

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Biomarkers of Ovarian Reserve Are Not Always Effective for Predicting Conception

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Reviewing Author