Antibody-Associated CNS Syndromes Without Inflammation in Elders

Nearly one quarter of patients aged ≥60 with neuronal cell surface antibodies and central nervous system syndromes had normal brain imaging and no cerebrospinal fluid pleocytosis.

The most frequent diagnostic criteria for encephalitis of any cause are decreased level of consciousness and inflammation demonstrated by brain magnetic resonance imaging (MRI) or cerebrospinal fluid (CSF) pleocytosis. However, as is seen in IgLON5 syndrome, some antibody-associated CNS syndromes involve inflammation only rarely. Also, older patients presenting with autoimmune encephalitis (AE) or other inflammatory central nervous system (CNS) disorders may not have evidence of inflammation on neuroimaging or CSF analysis.

Researchers retrospectively reviewed patients aged ≥60 whose serum or CSF samples showed antibodies against neuronal cell surface antigens when tested at a single research laboratory. Of 155 patients with such antibodies …

Reviewing Author

John C. Probasco, MD

Disclosures

Grant/Research Support Genetech/Roche

Editorial BoardsThe Neurohospitalist

Leadership Positions in Professional SocietiesNeurohospitalist Society (President; Chair, Research Subcommittee)

John C. Probasco, MD

Disclosures

Grant/Research Support Genetech/Roche

Editorial BoardsThe Neurohospitalist

Leadership Positions in Professional SocietiesNeurohospitalist Society (President; Chair, Research Subcommittee)

Antibody-Associated CNS Syndromes Without Inflammation in Elders

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Reviewing Author