A modeling study, in which 40,000 men who have sex with men initiate event-driven preexposure prophylaxis during a 15-year period, shows that 25% of new HIV infections could be averted by this cost-effective and ultimately cost-saving program.
Despite wide antiretroviral therapy (ART) coverage and virologic suppression, HIV incidence among men who have sex with men (MSM) in the U.K. remains high (rate, ~6 per 1000 person-years and 3500 new infections annually). Pre-exposure prophylaxis (PrEP), particularly event-driven PrEP, could help decrease HIV infections among MSM, but questions about the cost and cost-effectiveness of such a program remain.
Investigators in the U.K. undertook a modeling study and health economic evaluation of this issue. Estimating 8,400–12,200 eligible recipients, ~4000 would start event-driven PrEP the first year, with a gradual uptake to ~39,000 MSM by the end of a 15-year program. Each individual would receive PrEP for a mean 4.5 years.
The model predicte…
Reviewing Author
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)
DisclosuresGrant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; NIH/National Institute on Drug Abuse
Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes; Vaccines
Leadership Positions in Professional SocietiesInternational Antiviral Society–USA (Board of Directors); Infectious Diseases Society of America (Past President)