Do ACE Inhibitors or Statins Alter Albumin Excretion in Adolescents with Type 1 Diabetes?

Adolescents with type 1 diabetes (T1D) experience rapid increases in albumin excretion, a precursor to microalbuminuria and macroalbuminuria, as well as deterioration in other markers of cardiovascular health. To determine whether angiotensin-converting–enzyme (ACE) inhibitors or statins (commonly used in adults with T1D) benefit adolescents, investigators in the U.K., Canada, and Australia screened roughly 4400 patients aged 10 to 16 years who had T1D for at least 1 year. Of these, 443 patients with albumin-to-creatinine ratios in the upper third of those screened were randomized to receive quinapril (5–10 mg per day) plus placebo, atorvastatin (10 mg per day) plus placebo, quinapril plus atorvastatin, or two placebos.

The primary outcome w…