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The contribution of procedural areas and common areas of the hospital to hospital-acquired Clostridium difficile infection (CDI) are not well known. To better understand the benefit of targeted infection control efforts, the authors conducted a retrospective case–control study in a single large medical center. The investigators assessed electronic health records (EHRs) to analyze patient visits to multiple units and hospital common areas (e.g., computed tomography[CT], radiation oncology). Exposed patients were CDI-negative patients visiting an area within 24 hours after a CDI-positive patient; follow-up was 60 days. Patients visiting that space during an “uncontaminated” period served as controls. Logistic regression was used to correct fo…