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Female contraceptive hormones have been linked repeatedly to risk for depression (NEJM JW Psychiatry Dec 2016 and JAMA Psychiatry 2016; 73:1154), but studies into possible links between contraceptive hormone use and suicide risk have been inconclusive. The current investigators used Danish national prescription, psychiatric, and death registries to prospectively study this possible association.
The study included 475,802 females who turned age 15 between 1996 and 2013 and who had no history of contraceptive or antidepressant use, suicide attempts, or diagnoses of psychiatric disorders, cancer, or venous thrombosis. At mean follow-up of 8 years, 54% of participants (mean age, 21; maximum age, 33) had used contraceptive hormones. Comparisons b…