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Psychiatric clinicians are frequently called upon to diagnose and manage persistent psychoses subsequent to substance-induced psychotic episodes. To investigate these phenomena, investigators used Danish national registry data on 6788 patients (75% male) diagnosed from 1994 through 2014 with substance-induced psychosis (alcohol, 34%; cannabis, 22%; mixed/other substances, 27%) but with no prior diagnoses of schizophrenia-spectrum or bipolar disorders. Case patients were age- and sex-matched to 67,277 controls never diagnosed with schizophrenia or bipolar disorder.
Over the 20 years, 32% of case patients received diagnoses of schizophrenia or bipolar disorder, more typically for schizophrenia. The highest rate of conversion to either diagnosi…